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The only FDA-approved, once-yearly CPP treatment

Only the SUPPRELIN® LA implant provides your child with 1 year of hormone medicine, histrelin acetate

  • A single dose of SUPPRELIN® LA provides 1 full year of medication in 1 implant to help provide hormone suppression through Month 12 after the first month of therapy
  • The implant needs to be removed after 12 months. A new implant can be inserted if you, your family, and your child’s healthcare professional decide to continue treatment
  • In a clinical trial, 97% of families continued with SUPPRELIN® LA when a healthcare professional recommended further CPP treatment for their child

Your child must have regular visits with his or her pediatric endocrinologist while undergoing treatment for CPP

A healthcare professional will perform regular exams and blood tests to check for signs of puberty, measure height and weight, and may take wrist X-rays to track bone growth.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

Watch One Girl's CPP Journey

A nurse—and mom—tells her daughter's CPP treatment story.

What to expect with SUPPRELIN® Long-Acting

One full year of medication in one implant

One implant provides 1 year of continuous hormone medicine, histrelin acetate. This treats your child's CPP for a full year after the first month of therapy.

Insertion procedure
  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm
  • A pediatric surgeon usually inserts the implant
  • The entire procedure can be done in a doctor's office using a local anesthetic. Your child's healthcare professional will recommend the appropriate setting
  • A healthcare professional will temporarily numb your child's upper arm, make a small cut, and insert the implant just under the skin
  • A healthcare professional will then close the cut with stitches or surgical strips and cover with a bandage
After-care

Follow these instructions after the procedure. Always remember to follow the advice of your child's healthcare professional

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours
  • The bandage can be removed after 24 hours
  • Do not remove the surgical strips. They will fall off on their own in a few days
  • Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions
  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child’s doctor right away if the SUPPRELIN® LA implant comes through the skin

Follow-up visits are important

Your child must have regular visits with his or her pediatric endocrinologist. Your child may need blood tests a month after the procedure and every 6 months after that. A healthcare professional will also check for signs of puberty, measure height, and may take wrist X-rays to track bone growth.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

The SUPPRELIN® LA Support Center

See how the SUPPRELIN® LA Support Center may help your child have access to SUPPRELIN® LA.

A new implant can be inserted if you, your family, and your child's healthcare professional decide to continue treatment

  • The SUPPRELIN® Long-Acting implant needs to be removed after 12 months

SUPPRELIN® LA is designed to allow for a few additional weeks of medicine beyond 12 months, so you can be flexible when making medical appointments

Length of treatment

Your child's healthcare professional will decide when to end treatment so that puberty can begin as normal—usually around age 11 in girls and age 12 in boys.

Follow-up visits are important

Your child must have regular visits with his or her pediatric endocrinologist. A healthcare professional will perform regular exams and blood tests to check for signs of puberty, measure height and weight, and may take wrist X-rays to track bone growth.

What Are My Child's
Treatment Options?

Find the CPP treatment that works with your child's life.

The SUPPRELIN® LA Support Center

See how the SUPPRELIN® LA Support Center may help your child have access to SUPPRELIN® LA.

Potential side effects

  • You may notice more signs of puberty in the first week of treatment and new signs may develop. You should see evidence that puberty is stopping within 4 weeks of treatment
  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks
  • Call your child’s healthcare professional if he or she has bleeding, redness, or pain at the insertion site
  • Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)
  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems and seizures. Call your child's doctor right away if they experience these events

Ask your child's healthcare professional for more information or see Important Safety Information for further details.

These may not be all the side effects of SUPPRELIN® LA

This information does not replace counseling from a healthcare professional.

About CPP

Get a better understanding of your child's condition.

What Are My Child's
Treatment Options?

Find the CPP treatment that works with your child’s life.

WHAT IS SUPPRELIN® LA?
  • SUPPRELIN® LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN® LA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA
  • SUPPRELIN® LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN® LA implant, or is pregnant or becomes pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN® LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN® LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN® LA tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN® LA.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN® LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN® LA.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN® LA. SUPPRELIN® LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment.

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN® LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide, for SUPPRELIN® LA.

More Safety Info
WHAT IS SUPPRELIN® LA?
  • SUPPRELIN® LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN® LA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA
  • SUPPRELIN® LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN® LA implant, or is pregnant or becomes pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN® LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN® LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN® LA tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN® LA.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN® LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN® LA.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN® LA. SUPPRELIN® LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment.

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN® LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide, for SUPPRELIN® LA.

Intended for U.S. Residents Only

Rx Only

SUPPRELIN® is a registered trademark of Endo International plc or one of its affiliates.

© 2017 Endo Pharmaceuticals Inc. All rights reserved. Malvern, PA 19355

  • Privacy/Legal
  • SP-05167/June 2017
  • www.supprelinla.com
  • 1-800-462-ENDO (3636)
What is SUPPRELIN® LA?
IMPORTANT SAFETY INFORMATION
WHAT IS SUPPRELIN® LA?
  • SUPPRELIN® LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN® LA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA
  • SUPPRELIN® LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN® LA implant, or is pregnant or becomes pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN® LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN® LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN® LA tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN® LA.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN® LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN® LA.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN® LA. SUPPRELIN® LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment.

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN® LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide, for SUPPRELIN® LA.