We're sorry but our site requires JavaScript.

What is CPP?

Early puberty

During puberty, girls begin producing extra estrogen in the ovaries and boys begin producing extra testosterone in the testicles. These hormones produce the physical and emotional changes associated with puberty such as breast development in girls and enlarged testicles and penis in boys.

Your child’s healthcare professional should do tests to confirm a diagnosis of CPP before beginning treatment

When certain hormones are released too soon, a child can enter puberty earlier than he or she should. This may be the result of a condition called central precocious puberty (CPP). There is no direct cause for CPP in most cases, but in rare cases it may be due to an underlying medical condition.

What Are My Child’s
Treatment Options?

Find the CPP treatment that works with your child’s life.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

Why treat CPP?

Full growth potential

Puberty usually causes a growth spurt. So, right now, your child might be taller than his or her peers, but a growth spurt that happens too early may mean your child could end up shorter as an adult than he or she might otherwise have been.

CPP treatments stop the puberty signal

Your child’s healthcare professional may recommend a medicine called a GnRH agonist. This is a medicine that can help stop puberty by blocking the release of sex hormones in the body.

Helping your child cope with CPP

Just talking to your child about the condition can make a big difference. Let him or her know that puberty is a normal process that everyone goes through; but, for some children, puberty happens earlier than it should.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

About SUPPRELIN® LA

Learn more about the only once-yearly CPP treatment that suppresses puberty-causing hormones through Month 12 after the first month of therapy.

Considering treatment options to fit your child’s life

Talk to your doctor about what treatment options may fit with your child’s needs

There are many CPP therapies available that can stop the release of puberty-causing hormones. Take a look at your treatment options.

Some questions to consider
  • How could each of these treatments affect your child’s experience with CPP?
  • What is your family’s schedule like throughout the year?
  • Do you worry about missing medical appointments?

You should keep all scheduled visits to the doctor. Your child’s doctor will do regular exams and a blood test to check for signs of puberty

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

The SUPPRELIN® LA Support Center

See how the SUPPRELIN® LA Support Center may help your child have access to SUPPRELIN® LA.

WHAT IS SUPPRELIN® LA?
  • SUPPRELIN® LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN® LA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA
  • SUPPRELIN® LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN® LA implant, or is pregnant or becomes pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN® LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN® LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN® LA tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN® LA.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN® LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN® LA.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN® LA. SUPPRELIN® LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment.

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN® LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide, for SUPPRELIN® LA.

More Safety Info
WHAT IS SUPPRELIN® LA?
  • SUPPRELIN® LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN® LA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA
  • SUPPRELIN® LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN® LA implant, or is pregnant or becomes pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN® LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN® LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN® LA tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN® LA.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN® LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN® LA.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN® LA. SUPPRELIN® LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment.

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN® LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide, for SUPPRELIN® LA.

Intended for U.S. Residents Only

Rx Only

SUPPRELIN® is a registered trademark of Endo International plc or one of its affiliates.

© 2017 Endo Pharmaceuticals Inc. All rights reserved. Malvern, PA 19355

  • Privacy/Legal
  • SP-05167/June 2017
  • www.supprelinla.com
  • 1-800-462-ENDO (3636)
What is SUPPRELIN® LA?
IMPORTANT SAFETY INFORMATION
WHAT IS SUPPRELIN® LA?
  • SUPPRELIN® LA is an implanted gonadotropin releasing hormone (GnRH) medicine used for the treatment of children with central precocious puberty (CPP).

  • It is not known if SUPPRELIN® LA is safe and effective in children under 2 years of age.

IMPORTANT SAFETY INFORMATION ABOUT SUPPRELIN® LA
  • SUPPRELIN® LA should not be taken if your child is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or any ingredients in the SUPPRELIN® LA implant, or is pregnant or becomes pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby. If your child becomes pregnant, call your doctor.

  • In the first week of treatment, SUPPRELIN® LA can cause an increase in some hormones. During this time, you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping.

  • Some people who had SUPPRELIN® LA placed in their arm have had the implant come through the skin (extrusion). Call your child's doctor right away if the SUPPRELIN® LA implant comes through the skin.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had new or worsening mental (psychiatric) problems including depression. Mental (psychiatric) problems may include emotional symptoms such as crying, irritability, restlessness (impatience), anger, and acting aggressive. Before your child receives SUPPRELIN® LA tell the doctor if they have a history of mental problems. Call your child's doctor right away if your child has any new or worsening mental symptoms or problems while taking SUPPRELIN® LA.

  • Some people taking GnRH agonists like SUPPRELIN® LA have had seizures. The risk of seizures may be higher in people who have a history of seizures, epilepsy, brain or brain vessel (cerebrovascular) problems or tumors, or who are taking a medicine that has been connected to seizures such as bupropion or selective serotonin reuptake inhibitors (SSRIs). Seizures have also happened in people who have not had any of these problems. Before your child receives SUPPRELIN® LA, tell the doctor if they have a history of these problems, as well as all the medicines they take. Call your child's doctor right away if your child has a seizure while taking SUPPRELIN® LA.

  • Your child's doctor should do tests to make sure your child has CPP before treating with SUPPRELIN® LA. SUPPRELIN® LA lasts for 12 months. One implant will give the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment.

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage.

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours after receiving the SUPPRELIN® LA implant. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in a few days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions.

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. Sometimes the doctor will have to do special tests, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin.

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. These reactions may include pain, redness, bruising, soreness, and swelling in and around the implant site. Call your child's doctor if your child has bleeding, redness, or severe pain where the implant was inserted.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide, for SUPPRELIN® LA.