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What is CPP?

Early puberty

During puberty, girls begin producing extra estrogen in the ovaries and boys begin producing extra testosterone in the testicles. These hormones produce the physical and emotional changes associated with puberty such as breast development in girls and enlarged testicles and penis in boys.

Your child’s healthcare professional should do tests to confirm a diagnosis of CPP before beginning treatment

When certain hormones are released too soon, a child can enter puberty earlier than he or she should. This may be the result of a condition called central precocious puberty (CPP). There is no direct cause for CPP in most cases, but in rare cases it may be due to an underlying medical condition.

What Are My Child’s
Treatment Options?

Find the CPP treatment that works with your child’s life.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

Why treat CPP?

Full growth potential

Puberty usually causes a growth spurt. So, right now, your child might be taller than his or her peers but a growth spurt that happens too early may mean your child could end up shorter as an adult than he or she might otherwise have been.

CPP treatments stop the puberty signal

Your child’s healthcare professional may recommend a medicine called a GnRH agonist. This is a medicine that can help stop puberty by blocking the release of sex hormones in the body.

Helping your child cope with CPP

Just talking to your child about the condition can make a big difference. Let him or her know that puberty is a normal process that everyone goes through; but, for some children, puberty happens earlier than it should.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

About SUPPRELIN® LA

Learn more about the only once-yearly CPP treatment that suppresses puberty-causing hormones through month 12 after the first month of therapy.

Considering treatment options to fit your child’s life

Talk to your doctor about what treament options may fit with your child’s needs

There are many CPP therapies available that can stop the release of puberty-causing hormones. Take a look at your treatment options.

Some questions to consider
  • How could each of these treatments affect your child’s experience with CPP?
  • What is your family’s schedule like throughout the year?
  • Do you worry about missing medical appointments?

You should keep all scheduled visits to the doctor. Your child’s doctor will do regular exams and a blood test to check for signs of puberty

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

The SUPPRELIN® LA Support Center

See how the SUPPRELIN® LA Support Center may help your child have access to SUPPRELIN® LA.

What is SUPPRELIN® LA?
  • SUPPRELIN® LA (histrelin acetate) is an under-the-skin (subcutaneous) implant that contains the medicine histrelin, a gonadotropin releasing hormone (GnRH). SUPPRELIN® LA is used for treatment of children with central precocious puberty (CPP)

  • CPP makes puberty come early in girls (before 8 years of age) and in boys (before 9 years of age). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. SUPPRELIN® LA works by reducing the amount of sex hormones in the blood to delay early puberty

  • Your child's doctor should do tests to make sure your child has CPP before treating your child with SUPPRELIN® LA

IMPORTANT SAFETY INFORMATION about SUPPRELIN® LA
  • Your child should not use SUPPRELIN® LA if he/she is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or anything in the SUPPRELIN® LA implant. Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)

  • SUPPRELIN® LA should not be used in children under 2 years of age or in women who are or may become pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby

  • In the first few weeks of treatment, SUPPRELIN® LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. In rare cases, SUPPRELIN® LA may be ejected from the body through the insertion site, without your child noticing. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. SUPPRELIN® LA lasts for 12 months. One implant provides the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment. Sometimes the doctor will have to do special examinations, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks. Call your child's doctor if your child has bleeding, redness or pain at the insertion site

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.

More Safety Info
What is SUPPRELIN® LA?
  • SUPPRELIN® LA (histrelin acetate) is an under-the-skin (subcutaneous) implant that contains the medicine histrelin, a gonadotropin releasing hormone (GnRH). SUPPRELIN® LA is used for treatment of children with central precocious puberty (CPP)

  • CPP makes puberty come early in girls (before 8 years of age) and in boys (before 9 years of age). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. SUPPRELIN® LA works by reducing the amount of sex hormones in the blood to delay early puberty

  • Your child's doctor should do tests to make sure your child has CPP before treating your child with SUPPRELIN® LA

IMPORTANT SAFETY INFORMATION about SUPPRELIN® LA
  • Your child should not use SUPPRELIN® LA if he/she is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or anything in the SUPPRELIN® LA implant. Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)

  • SUPPRELIN® LA should not be used in children under 2 years of age or in women who are or may become pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby

  • In the first few weeks of treatment, SUPPRELIN® LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. In rare cases, SUPPRELIN® LA may be ejected from the body through the insertion site, without your child noticing. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. SUPPRELIN® LA lasts for 12 months. One implant provides the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment. Sometimes the doctor will have to do special examinations, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks. Call your child's doctor if your child has bleeding, redness or pain at the insertion site

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.

Intended for U.S. Residents Only

Rx Only

SUPPRELIN® is a registered trademark of Endo International plc or one of its affiliates.

© 2016 Endo Pharmaceuticals Inc. All rights reserved. Malvern, PA 19355

  • Privacy/Legal
  • SP-05028/November 2016
  • www.supprelinla.com
  • 1-800-462-ENDO (3636)
What is SUPPRELIN® LA?
INDICATION & IMPORTANT SAFETY INFO
What is SUPPRELIN® LA?
  • SUPPRELIN® LA (histrelin acetate) is an under-the-skin (subcutaneous) implant that contains the medicine histrelin, a gonadotropin releasing hormone (GnRH). SUPPRELIN® LA is used for treatment of children with central precocious puberty (CPP)

  • CPP makes puberty come early in girls (before 8 years of age) and in boys (before 9 years of age). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. SUPPRELIN® LA works by reducing the amount of sex hormones in the blood to delay early puberty

  • Your child's doctor should do tests to make sure your child has CPP before treating your child with SUPPRELIN® LA

IMPORTANT SAFETY INFORMATION about SUPPRELIN® LA
  • Your child should not use SUPPRELIN® LA if he/she is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or anything in the SUPPRELIN® LA implant. Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)

  • SUPPRELIN® LA should not be used in children under 2 years of age or in women who are or may become pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby

  • In the first few weeks of treatment, SUPPRELIN® LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. In rare cases, SUPPRELIN® LA may be ejected from the body through the insertion site, without your child noticing. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. SUPPRELIN® LA lasts for 12 months. One implant provides the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment. Sometimes the doctor will have to do special examinations, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks. Call your child's doctor if your child has bleeding, redness or pain at the insertion site

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.