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SUPPRELIN® LA Connection Video Library

Meet Rebecca, an endocrinology nurse and mom

Hear from a mother—and nurse—whose child is being treated with SUPPRELIN® LA.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.

Inserting the SUPPRELIN® LA Implant

Removing the SUPPRELIN® LA Implant

About SUPPRELIN® LA

Learn more about the only once-yearly CPP treatment that suppresses puberty-causing hormones through month 12 after the first month of therapy.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

Caregiver Information

Here are some helpful links and downloadable content

About SUPPRELIN® LA

Learn more about the only once-yearly CPP treatment that suppresses puberty-causing hormones through month 12 after the first month of therapy.

SHARES Program

See how the SUPPRELIN® LA SHARES Program may help lower the cost of treatment.

Endo Pharmaceuticals Inc. does not endorse or control any content on these pages. All trademarks are property of their respective owners.

What is SUPPRELIN® LA?
  • SUPPRELIN® LA (histrelin acetate) is an under-the-skin (subcutaneous) implant that contains the medicine histrelin, a gonadotropin releasing hormone (GnRH). SUPPRELIN® LA is used for treatment of children with central precocious puberty (CPP)

  • CPP makes puberty come early in girls (before 8 years of age) and in boys (before 9 years of age). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. SUPPRELIN® LA works by reducing the amount of sex hormones in the blood to delay early puberty

  • Your child's doctor should do tests to make sure your child has CPP before treating your child with SUPPRELIN® LA

IMPORTANT SAFETY INFORMATION about SUPPRELIN® LA
  • Your child should not use SUPPRELIN® LA if he/she is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or anything in the SUPPRELIN® LA implant. Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)

  • SUPPRELIN® LA should not be used in children under 2 years of age or in women who are or may become pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby

  • In the first few weeks of treatment, SUPPRELIN® LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. In rare cases, SUPPRELIN® LA may be ejected from the body through the insertion site, without your child noticing. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. SUPPRELIN® LA lasts for 12 months. One implant provides the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment. Sometimes the doctor will have to do special examinations, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks. Call your child's doctor if your child has bleeding, redness or pain at the insertion site

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.

More Safety Info
What is SUPPRELIN® LA?
  • SUPPRELIN® LA (histrelin acetate) is an under-the-skin (subcutaneous) implant that contains the medicine histrelin, a gonadotropin releasing hormone (GnRH). SUPPRELIN® LA is used for treatment of children with central precocious puberty (CPP)

  • CPP makes puberty come early in girls (before 8 years of age) and in boys (before 9 years of age). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. SUPPRELIN® LA works by reducing the amount of sex hormones in the blood to delay early puberty

  • Your child's doctor should do tests to make sure your child has CPP before treating your child with SUPPRELIN® LA

IMPORTANT SAFETY INFORMATION about SUPPRELIN® LA
  • Your child should not use SUPPRELIN® LA if he/she is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or anything in the SUPPRELIN® LA implant. Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)

  • SUPPRELIN® LA should not be used in children under 2 years of age or in women who are or may become pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby

  • In the first few weeks of treatment, SUPPRELIN® LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. In rare cases, SUPPRELIN® LA may be ejected from the body through the insertion site, without your child noticing. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. SUPPRELIN® LA lasts for 12 months. One implant provides the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment. Sometimes the doctor will have to do special examinations, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks. Call your child's doctor if your child has bleeding, redness or pain at the insertion site

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.

Intended for U.S. Residents Only

Rx Only

SUPPRELIN® is a registered trademark of Endo International plc or one of its affiliates.

© 2016 Endo Pharmaceuticals Inc. All rights reserved. Malvern, PA 19355

  • Privacy/Legal
  • SP-05028/November 2016
  • www.supprelinla.com
  • 1-800-462-ENDO (3636)
What is SUPPRELIN® LA?
INDICATION & IMPORTANT SAFETY INFO
What is SUPPRELIN® LA?
  • SUPPRELIN® LA (histrelin acetate) is an under-the-skin (subcutaneous) implant that contains the medicine histrelin, a gonadotropin releasing hormone (GnRH). SUPPRELIN® LA is used for treatment of children with central precocious puberty (CPP)

  • CPP makes puberty come early in girls (before 8 years of age) and in boys (before 9 years of age). Signs of early puberty include breast enlargement in girls and the appearance of hair in the genital area in boys and girls. SUPPRELIN® LA works by reducing the amount of sex hormones in the blood to delay early puberty

  • Your child's doctor should do tests to make sure your child has CPP before treating your child with SUPPRELIN® LA

IMPORTANT SAFETY INFORMATION about SUPPRELIN® LA
  • Your child should not use SUPPRELIN® LA if he/she is allergic to gonadotropin releasing hormone (GnRH), GnRH agonist medicines, or anything in the SUPPRELIN® LA implant. Serious and life-threatening allergic reactions have happened with GnRH medicines (the type of medicine in SUPPRELIN® LA)

  • SUPPRELIN® LA should not be used in children under 2 years of age or in women who are or may become pregnant. SUPPRELIN® LA can cause birth defects or loss of the baby

  • In the first few weeks of treatment, SUPPRELIN® LA can cause a brief increase in some hormones, and during this time you may notice more signs of puberty in your child, including light vaginal bleeding and breast enlargement in girls. Within 4 weeks of treatment, you should see signs in your child that puberty is stopping

  • SUPPRELIN® LA is placed under the skin of the inside of the upper arm. The doctor will temporarily numb the arm of your child, make a small cut, and then place SUPPRELIN® LA under the skin. The cut may be closed with stitches or surgical strips and covered with a pressure bandage

  • Your child should keep the arm clean and dry and should not swim or bathe for 24 hours. The bandage can be removed after 24 hours. Do not remove any surgical strips. They will fall off on their own in several days. Your child should avoid heavy play or exercise that uses the implanted arm for 7 days. In rare cases, SUPPRELIN® LA may be ejected from the body through the insertion site, without your child noticing. You and your child should routinely check the insertion site until the cut is healed. After the cut has healed, your child can go back to his or her normal activities. The doctor will give you complete instructions

  • Keep all scheduled visits to the doctor. Your child's doctor will do regular exams and blood tests to check for signs of puberty. SUPPRELIN® LA lasts for 12 months. One implant provides the medicine for 12 months. After 12 months, SUPPRELIN® LA must be removed. The doctor may insert a new SUPPRELIN® LA at this time to continue treatment. Sometimes the doctor will have to do special examinations, such as ultrasound or MRI, if the SUPPRELIN® LA implant is difficult to find under your child's skin

  • The most common side effects of SUPPRELIN® LA are skin reactions at the place where the implant is inserted. Such reactions may include bruising, soreness, pain, tingling, itching, and swelling. They usually go away without treatment within 2 weeks. Call your child's doctor if your child has bleeding, redness or pain at the insertion site

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Labeling for SUPPRELIN® LA.